Scientists appear to have unlocked clues behind inflammation in allergic reactions.
Texans are likely familiar with allergies and the variety of effects they can create in one’s body. Data from the National Phenology Network indicated that the spring allergy season arrived early in North Texas, as previously reported by The Dallas Express.
Two National Centre for Scientific Research and Inserm scientists working at the l’Institut de pharmacologie et de biologie structural in Toulouse, France, have discovered a molecule that is responsible for triggering inflammation in allergic reactions. These scientists have identified this molecule as TL1A, a member of the alarmin family of molecules.
This molecule was found minutes after a mold allergen was introduced into the respiratory system. TL1A was found to generate a “double alarm” signal, cooperating alongside another molecule of the same family, interleukin-33. The signal stimulates the immune system, causing reactions resulting in allergic inflammation, per the press release.
Scientists hope this research will inform treatment options for people with allergic respiratory diseases, including allergic rhinitis and asthma.
“Alarmins, therefore, constitute major therapeutic targets for the treatment of respiratory allergic diseases. In a few years’ time, treatments based on antibodies blocking the TL1A alarmin could benefit patients suffering from severe asthma or other allergic diseases,” noted the press release.
