The Associated Press reported that the 2025 Nobel Prize in Physiology or Medicine was awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discoveries showing how regulatory T cells and the Foxp3 gene enforce peripheral immune tolerance. The Karolinska Institute announced the award Monday, marking the start of this year’s Nobel season.

Their work explains how the immune system avoids attacking the body — a breakthrough that has guided research into treatments for autoimmune diseases, transplant tolerance, and cancer. Experts called the findings decisive, though clinical applications remain in development.

The DX Brief

  • Nobel Prize in Medicine awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discoveries on regulatory T cells, Foxp3, and immune tolerance
  • Laureates’ affiliations include the Institute for Systems Biology, Sonoma Biotherapeutics, and Osaka University
  • First of the 2025 Nobel announcements; physics, chemistry, literature, peace, and economics prizes to follow
  • Findings inform autoimmune, transplant, and cancer research; experts praise the impact as therapies advance
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Read the full article at AP News.