College football enters Week 6 this weekend. Here are some notable matchups worth monitoring across the country.

SATURDAY
No.23 LSU (3-2, 2-1 SEC) at No.21 Missouri (5-0, 1-0), 11 a.m. CT, ESPN
LSU came out on the wrong end of a high-scoring affair at Ole Miss last week, proving once again that it can score but has a defense prone to struggles against good teams. Meanwhile, Missouri is a surprise team, and a win would make it bowl-eligible and continue its undefeated season — not to mention catapult it into possible SEC contention.

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No.13 Washington State (4-0, 1-0 Pac-12) at UCLA (3-1, 0-1 Pac-12), 2 p.m. CT, PAC-12 Network
The PAC-12 has proven to be a deep conference in its final season. Several teams, including these two, are still in the title race. Washington State began the year unranked but has surged under the leadership of head coach Jake Dickert and the play-making ability of quarterback Cam Ward. UCLA’s offense struggled in a low-scoring loss to Utah, but true freshman quarterback Dante Moore has been incredibly impressive. This could be a high-scoring game as both schools fight to stay in the PAC-12 race.

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No.20 Kentucky (5-0, 2-0 SEC) at No.1 Georgia (5-0, 2-0 SEC), 6 p.m. CT, ESPN
Kentucky enters the Top 25 after upsetting Florida. The Wildcats have been a dynamic offense all year, averaging 37 points per game behind North Carolina State transfer quarterback Devin Leary. Georgia has struggled early in each of its SEC matchups this season but found a way to gut out tough wins. Can the Wildcats pull off the upset, or will the Bulldogs find a way to win again?

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No.10 Notre Dame (5-1) at No.25 Louisville (5-0, 3-0 ACC), 6:30 p.m. CT, ABC
Notre Dame continued its roll after a last-second loss to Ohio State with a hard-fought win over Duke last week. The Fighting Irish, led by Wake Forest transfer Sam Hartmann and the nation’s leading rusher Audric Estime, have looked every bit like a top-10 team this season. Meanwhile, Louisville is another surprise team claiming a place in the Top 25. The Cardinals are putting up nearly 500 yards of offense, but their defense may not be enough to handle the Irish offense.